Human Gut Microbiome-Based Contract Research Applications in Toxicology and Microbiome-Based Drug Discovery

The human gut microbiome contains a complex aggregate of colonic bacterial enzymes mediating the metabolism of a wide range of xenobiotics and dietary components. From a toxicology context, this presentation highlights examples of pre-systematic drug clearance mediated by colonic enzymes contributing to systemic metabolite exposure. In vitro and in vivo studies to provide mechanistic contributions of metabolite systemic exposure will be reviewed.