Pregabalin, (S)-3-(aminomethyl)-5-methylhexanoic acid, is an analog of the neurotransmitter gamma amino butyric acid (GABA), used for the treatment of peripheral and central neuropathic pain in adults and as adjunctive therapy for refractory partial seizures. The aim of this study is to develop a sensitive, specific, robust, and rapid LC-MS/MS method, using a simple extraction procedure with no interference from the matrix and with a short run time.
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Midazolam is a widely used central nervous system depressant. It is used for the treatment of insomnia, seizure, and induction of sedation or amnesia for operations. It is metabolized by cytochrome CYP3A and is a widely used probing drug for the evaluation of CYP3A activity in drug-to-drug interaction (DDI) studies. In this study, we develop a method to quantify midazolam in human plasma.
Hosted by ISSX, Frontage's own Dr John Kapeghian discusses the "Cost Effective and Efficient Progression of Lead Drug Candidates to First in Human Studies in the Two Largest Economies in the World: USA and China."
Fascin is an actin-bundling protein that has been linked to tumor cell migration, invasion, metastasis, disease progression and mortality, thus serving as a novel cancer biomarker. In this paper, we develop and validate an LC-MS/MS method for the quantification of fascin proteins in human serum.