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Determination of Pregabalin in Human Plasma by Liquid Chromatography Tandem…

Pregabalin, (S)-3-(aminomethyl)-5-methylhexanoic acid, is an analogue of the neurotransmitter gamma amino butyric acid (GABA). It is used for the treatment of peripheral and central neuropathic pain in adults and as an adjunctive therapy for refractory partial seizures. Pregabalin binds potently to the α2δ (alpha2delta) subunit of the voltage-dependent calcium channel in the central nervous system and its binding at this site reduces calcium influx at the nerve terminal, leading to the release of several neurotransmitters, such as glutamate and noradrenalin. The aim of this study is to develop a sensitive, specific, robust and rapid LC-MS/MS method: Use simple extraction procedure; With no interference from matrix; With short run time.

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