Midazolam is a widely used central nervous system depressant. It is used for the treatment of insomnia, seizure, and induction of sedation or amnesia for operations. It is metabolized by cytochrome CYP3A and is a widely used probing drug for the evaluation of CYP3A activity in drug-to-drug interaction (DDI) studies. In this study, we develop a method to quantify midazolam in human plasma.
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An Ultrasensitive LC-APPI-MS/MS Method for Simultaneous Determination of Ciclesonide and Active Metabolite Desisobutyryl-Ciclesonide in Human Serum and Its Application to a Clinical Study
Interleukin17A (IL-17A) is disulfide-linked homo dimeric cytokine of 155 amino acids and a member of an IL-17 family of related cytokines. There is now compelling evidence that patients affected by autoimmune diseases have a higher incidence of several cardiovascular diseases. In this study, we validate a method to quantify IL-17A in human serum using the ultrasensitive Quanterix Simoa™ platform.
In this poster, we validate ultra-high sensitive SIMOA assays for the successful quantitation of neurofilament light chain (NF-L) and glial fibrillary acidic protein (GFAP).