An Ultrasensitive LC-APPI-MS/MS Method for Simultaneous Determination of Ciclesonide and Active Metabolite Desisobutyryl-Ciclesonide in Human Serum and Its Application to a Clinical Study
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Interleukin17A (IL-17A) is disulfide-linked homo dimeric cytokine of 155 amino acids and a member of an IL-17 family of related cytokines. There is now compelling evidence that patients affected by autoimmune diseases have a higher incidence of several cardiovascular diseases. In this study, we validate a method to quantify IL-17A in human serum using the ultrasensitive Quanterix Simoa™ platform.
In this study, we discuss the development and validation of an LC-MS/MS method for the quantification of 15 bile acids in the human serum.
Fascin is an actin-bundling protein that has been linked to tumor cell migration, invasion, metastasis, disease progression and mortality, thus serving as a novel cancer biomarker. In this paper, we develop and validate an LC-MS/MS method for the quantification of fascin proteins in human serum.