ADME / Tox Screening

Frontage Global Drug Discovery Services (GDDS) offers a full spectrum of in vitro ADMET assays, including metabolic stability, drug-drug internation with P450 and transporters, permeability, protein binding, safety pharmacology panel and hERG.

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ADME / Tox Screening

Many investigational new drug (IND) applications fail during preclinical and clinical development due to the drug’s poor pharmacokinetic properties and toxicity, which result in a high attrition rate.

Early in vitro ADME studies, in parallel with approaches for optimizing the biochemical and cellular activities of the compounds, ensure that only the most promising compound is selected as your lead candidate.

Our strong focus on lab operations, automation, and project management enables efficient delivery and unparalleled quality.

Our team uses optimized in vitro testing systems (e.g., hepatocytes, liver microsomes) and access to analytical instruments such as high-throughput tandem mass spectrometry LC/MS/MS systems and robotic automation systems.

Explore ADMET Services at Frontage