Large Molecule Bioanalysis • Biologics & Bioassays


Comprehensive services in support of advanced development programs.

Gain access to comprehensive biologics services in support of advanced development programs with Frontage’s bioanalytical laboratory.

We have the capabilities to analyze virtually any peptide, protein, oligonucleotide, antibody or antibody-drug conjugates (ADC), and have built a reputation for solving technical challenges related to assay development and validation. 

Frontage’s biologics team have an average of 10 – 15 years in complex drug development and have worked with large molecule applications throughout its evolution in product development. We can handle projects for a range of large molecule development projects including peptides, proteins, monoclonal antibodies, multi-specific antibodies, biosimilars, oligonucleotides, biomarkers, and antibody-drug conjugates. 

  • Assay development and validation in complex biological matrix 
  • Biological sample analysis (plasma, serum, urine, cerebrospinal fluid, tissue, etc.) 
  • Antibody-Drug Conjugates (ADC) 
  • Determination of drug/antibody ratio (DAR) and development of DAR insensitive assay for ADC projects 
Biologics and Bioassays


Molecule Types 

  • Monoclonal antibodies 
  • Antibody conjugates (linker, toxins, MAb, etc)  
  • Multi-specific antibodies, antibody fragments  
  • Therapeutic proteins  
  • Single chain and fusion proteins  
  • Peptides  
  • Pegylated peptides or proteins 
  • Oligonucleotides, Cell & Gene Therapy  

Instrumentation Platforms 

Frontage offers the latest, state-of-the-art instrumentation for large molecule analysis. In addition, we offer Watson LIMS, a validated freezer temperature monitoring system, central security alarm monitoring, and 24-hour card-controlled facility access to ensure the highest levels of data integrity. 

Biologics and Bioassays
  • LC-MS/MS  
  • ELISA Assay (Colorimetric, Fluorescence, Chemiluminescence)   
  • MSD (Electrochemiluminescence)   
  • Quanterix Simoa    
  • PCR  
  • qPCR  
  • ddPCR  
  • Gyros  
  • Luminex  
  • Flow Cytometry  
  • ELLA  
  • ELISpot 

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