Current pharmacokinetic (PK) and toxicological studies pose an increasing demand on the volume of blood available from study animals, especially when the study involves small rodents. As a response, microsampling techniques have been introduced into bioanalytical studies.

Dried blood spots (DBS) and capillaries are the two most commonly used microsampling techniques. In this presentation, we present how microsampling can generate high quality bioanalytical data and accurate PK profiling, we also present a unique sample handling method utilizing pre-scored capillaries developed by Frontage (PA, USA), and how this overcomes some of the limitations with the conventional capillary microsampling approach.

With the development of more sensitive instrumentation, there is a greater need for smaller blood sample size analysis. In this paper, we validate a low-volume plasma LC-MS/MS method using a capillary microsampling (CMS) technique.

Current pharmacokinetic (PK) and toxicological studies pose an increasing demand for the volume of blood available from study animals. In this study, we discuss the advantages of Dried Blood Spot (DBS) and Capillary Microsampling (CMS) for toxicological and bioanalytical studies.