Current pharmacokinetic (PK) and toxicological studies pose an increasing demand on the volume of blood available from study animals, especially when the study involves small rodents. As a response, microsampling techniques have been introduced into bioanalytical studies.
Dried blood spots (DBS) and capillaries are the two most commonly used microsampling techniques. In this presentation, we present how microsampling can generate high quality bioanalytical data and accurate PK profiling, we also present a unique sample handling method utilizing pre-scored capillaries developed by Frontage (PA, USA), and how this overcomes some of the limitations with the conventional capillary microsampling approach.
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Current pharmacokinetic (PK) and toxicological studies
pose an increasing demand on the volume of blood
available from study animals.
Frontage stepped in to help a Sponsor that required development of a Neutralizing Antibody (NAB) method for an antibody drug that interrupts a Ligand: Receptor interaction. Previous attempts to develop a Cell-Based NAB had been unsuccessful and current attempts to develop a Competitive Ligand Binding assay were also having difficulty with method sensitivity, reproducibility and drug tolerance. Pipeline progression for this asset was halted until these issues could be resolved.