- Metabolic Stability
- CYP Interaction
- Permeability & Transporters
- Physicochemical Properties
- Protein Binding
Discovery PK and Toxicology
Exosomes are microscopic vesicles which are secreted by almost all cell types and are also present in almost every biological fluid. While exosomes were originally considered a mechanism to discarding unwanted cellular debris, today these nano-sized membrane vesicles are valued as highly relevant therapeutic targets for many diseases due their roles in disease transmission, intercellular cross-talk, angiogenesis, and inflammation. Specifically, exosomes are implicated in the progression of many diseases. Frontage provides comprehensive, end-to-end exosome isolation and purification services.
At Frontage, our Genomics team can isolate exosomes using a wide variety of techniques particularly well-suited for large volume samples.
Frontage can identify the size distribution and concentration of exosomes present in the biosamples prior to subsequent analysis. This quantitative and visual analysis provide a first characterization of the exosomes potentially involved in pathological processes of diseases including tumor and neurodegenerative diseases.
Investigations of exosome-bound genetic information, which can include long and small RNAs, can be used to identify cell– or tissue-specific markers and detect diagnostic and prognostic biomarkers useful for patient stratification or the determination of non-responders.
Frontage provides a comprehensive solution for exosomal RNA profiling.
Frontage offers characterization and quantitation of exosomal RNA of small and long RNA.
Our RNA sequencing services use a combination of state-of-the-art equipment that provides quick and accurate results for your RNA profiling projects.Learn More
Our customized laboratory and computational workflows enable cost-effective and rapid production of informative sequencing data sets.Learn More
Our Genomics team has extensive experience with a wide array of genomics services for pharmaceutical and clinical research in gene and cell therapy.Learn More