Medicinal Chemistry Services
- Metabolic Stability
- CYP Interaction
- Permeability & Transporters
- Physicochemical Properties
- Protein Binding
Discovery PK and Toxicology
Safety Pharmacology is an essential element of most small-molecule development programs and accompanies the general toxicology for IND filings. The purpose of safety pharmacology studies includes determining adverse effects, assessing and mitigating risks, and projecting a safety margin. At Frontage, we provide an incorporated approach to GLP safety pharmacology for regulatory purposes, and early non-GLP discovery pharmacology testing performed according to ICH S7A and S7B compliance from research and development to IND submission. We provide studies for in vitro safety pharmacology as well as in vivo safety pharmacology. Regardless of the approach, the molecule, or the therapeutic indication, Frontage can support your Safety Pharmacology studies.
We offer a core battery of studies including in vitro and in vivo cardiovascular (CV) testing as well as neuroscience (CNS) and respiratory assessments for your non-clinical programs.
Connect with our safety pharmacology experts.
At Frontage, we conduct CNS safety assessments either as a stand-alone or as an embedded endpoint in the general toxicology study.
At Frontage, we offer both in vitro and in vivo cardiovascular safety assessment services.
Our Respiratory Safety studies include whole-body plethysmography.
Frontage provides a full suite of safety assessment and toxicology services to guide new therapies from discovery to full drug candidate development support.