- Metabolic Stability
- CYP Interaction
- Permeability & Transporters
- Physicochemical Properties
- Protein Binding
Discovery PK and Toxicology
Advances in the preparation of bisulfite-converted DNA libraries and next-generation sequencing have enabled the measurement of methylation levels from the low amounts of input DNA present in plasma or serum samples. Specific genomic regions of interest, such as CpG islands, can be monitored using bisulfite sequencing through the selection of specific DNA sequences. Researchers can use methylation sequencing to understand the mechanisms that underlie complex diseases.
Frontage has developed and validated protocols for both targeted and global methylation analysis by sequencing and has optimized the isolation of cfDNA from liquid biopsy samples in order to minimize sample input requirements for this service.
Sample types include whole blood, serum, and plasma. Frontage provides cfDNA isolation services from blood-based biofluid samples. We are a Biosafety Level 2 (BSL-2) laboratory and can accept samples that contain agents associated with human disease.
|Sample Type||Minimum Input Requirement||Sample Submission Checklist|
|Cell-free DNA||10 ng||cfDNA|
Frontage is committed to providing rigorous scientific expertise to ensure the highest quality and compliance. Our drug discovery lab services team has the expertise to work with you across all stages of drug development.