Discovery
Medicinal Chemistry Services
Discovery ADME
- Metabolic Stability
- CYP Interaction
- Permeability & Transporters
- Physicochemical Properties
- Protein Binding
Genotoxicity (or genetic toxicity) refers to the mutagenic potential of a substance, or its ability to cause genetic mutations or chromosomal damage. Genotoxicity assessment is an essential component of the safety assessment of all types of substances, ranging from pharmaceuticals, industrial chemicals, pesticides, biocides, food additives, and cosmetics ingredients, to veterinary drugs, relevant in the context of international legislation aiming at the protection of human and animal health.
In general, the assessment of genotoxic hazards to humans follows a step-wise approach, beginning with a basic battery of in vitro tests followed in some cases by in vivo testing.
Frontage offers a portfolio of assays and designs to meet all regulatory requirements for IND in Genetic Toxicology testing.