Microbiome

Solving development problems of probiotics and prebiotics

Microbiome

At Frontage, our scientific team has over a decade of experience in Microbiome Services to help you solve the development problems of therapeutics, probiotics, and prebiotics.

We offer solutions for a wide range of indications including obesity, Type 2 diabetes, IBD, colorectal cancer, Immune diseases, bacterial and viral infections, and nervous system-related diseases (gut-brain axis)

  • Microbiome role in drug metabolism
  • Understanding of microbiome biological processes
  • Characterizations of major enzymatic pathways
  • Heterogeneity of fecal microbiome between individuals and between species
  • Standardize assays
  • Alterations in microbiome metabolism between healthy and patient populations

Human Gut Microbiome Metabolism

Our scientific team can provide high-quality data to help you advance your microbiome project.

  • Gut Metabolism
  • Gut Biomarkers
  • Gut Microbial Communities
  • Metabolomics

Webinar: Human Gut Microbiome-Based Contract Research Applications in Toxicology and Microbiome-Based Drug Discovery

Advanced Study Capabilities

1. In vitro anaerobic human gut microbiome metabolism studies in the following areas:

  • Determination of Km and Vmax enzyme kinetic parameters in pooled human gut microbiome for multiple classes of xenobiotics with reference to metabolic probes for nitroreduction, deglycosylation, deacetylation, deglucuronidation, etc.
  • Evaluation of microbiome-based formation of active metabolites
  • Evaluation of microbiome-based metabolism with reference to colonic population diversity data by whole genome Shotgun sequence data
  • Mechanistic study on metabolite formation by colonic genera/species
  • Elucidation of colonic bacteria-derived metabolite structure by HR-LC-MS/MS

Microbiome Graphic 300x244 1 - Microbiome

2. In Vitro Human Microbiome Enzyme Kinetics in Patients and Healthy Subjects

  • Determination of Km and Vmax enzyme kinetic parameters in pooled human gut microbiome for multiple classes of xenobiotics with reference to metabolic probes for nitroreduction, deglycosylation, deacetylation, deglucuronidation, etc.
  • Evaluation of microbiome-based formation of active metabolites
  • Evaluation of microbiome-based metabolism with reference to colonic population diversity data by whole genome Shotgun sequence data

Request a quote on your microbiome studies.

3. Comprehensive LBA and LC-MS/MS Assay Panels of Human Gut Microbiome Biomarkers in Fecal Homogenate and Plasma

  • Short-chain fatty acids
  • Hepatic and bacterial bile acids
  • Intestinal tight-junction biomarkers
  • Intestinal inflammatory and immune-modulating biomarker panels
  • Biomarkers assay panels by diseases and functions including inflammatory bowel diseases, cardiovascular, bone, neurodegeneration, oncology, and metabolic disorders including Type 2 diabetes

Metagenomics

Frontage offers advanced sequencing technologies that enable profiling of the microbiome DNA composition and the microbiome RNA composition at unprecedented scales.

Learn More