Microbiome

At Frontage, our scientific team has over a decade of experience in Microbiome Services to help you solve the development problems of therapeutics, probiotics, and prebiotics.

We offer solutions for a wide range of indications including obesity, Type 2 diabetes, IBD, colorectal cancer, Immune diseases, bacterial and viral infections, and nervous system-related diseases (gut-brain axis)

• Microbiome role in drug metabolism
• Understanding of microbiome biological processes
• Characterizations of major enzymatic pathways
• Heterogeneity of fecal microbiome between individuals and between species
• Standardize assays
• Alterations in microbiome metabolism between healthy and patient populations

Read our blog post on Harnessing the Microbiome Potential where we deep dive into the potential for data gathered from studying the gut microbiome in treating diseases.

Human Gut Microbiome Metabolism

Our scientific team can provide high-quality data to help you advance your microbiome project.

• Gut Metabolism
• Gut Biomarkers
• Gut Microbial Communities
• Metabolomics

Webinar: Human Gut Microbiome-Based Contract Research Applications in Toxicology and Microbiome-Based Drug Discovery

Advanced Study Capabilities

1. In vitro anaerobic human gut microbiome metabolism studies in the following areas:

• Determination of Km and Vmax enzyme kinetic parameters in pooled human gut microbiome for multiple classes of xenobiotics with reference to metabolic probes for nitroreduction, deglycosylation, deacetylation, deglucuronidation, etc.
• Evaluation of microbiome-based formation of active metabolites
• Evaluation of microbiome-based metabolism with reference to colonic population diversity data by whole genome Shotgun sequence data
• Mechanistic study on metabolite formation by colonic genera/species
• Elucidation of colonic bacteria-derived metabolite structure by HR-LC-MS/MS

2. In Vitro Human Microbiome Enzyme Kinetics in Patients and Healthy Subjects

• Determination of Km and Vmax enzyme kinetic parameters in pooled human gut microbiome for multiple classes of xenobiotics with reference to metabolic probes for nitroreduction, deglycosylation, deacetylation, deglucuronidation, etc.
• Evaluation of microbiome-based formation of active metabolites
• Evaluation of microbiome-based metabolism with reference to colonic population diversity data by whole genome Shotgun sequence data

Request a quote on your microbiome studies.

3. Comprehensive LBA and LC-MS/MS Assay Panels of Human Gut Microbiome Biomarkers in Fecal Homogenate and Plasma

• Short-chain fatty acids
• Hepatic and bacterial bile acids
• Intestinal tight-junction biomarkers
• Intestinal inflammatory and immune-modulating biomarker panels
• Biomarkers assay panels by diseases and functions including inflammatory bowel diseases, cardiovascular, bone, neurodegeneration, oncology, and metabolic disorders including Type 2 diabetes