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Resource Library / Overcoming Stability Issues in the Development of an LC-MS/MS Method for the Quantitation of Azacitidine in Human Plasma

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Overcoming Stability Issues in the Development of an LC-MS/MS Method for the Quantitation of Azacitidine in Human Plasma

In this study, we develop an LC-MS/MS assay for quantifying Azacitidine in Human Plasma and apply this method to support a phase ½ clinical study on the efficacy of Azacitidine in cancer subjects.

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WRIB 2025: Innovative Strategy for Overcoming pH-Related Assay Variation in the Development and Validation of a Pharmacokinetic Assay for OBI-992, a TROP2-Targeting Exatecan-Based Antibody-Drug Conjugate, in Human Serum
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Testing of Carryover & After MRD Benchtop Stability for Pharmacokinetic Method Validation in Gyrolab Immunoassay Platform
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Testing of Carryover & After MRD Benchtop Stability for...
In this white paper, we show testing of two critical parameters for the method validation ...
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Stability Testing
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Stability Testing
Assessing a compound’s stability is a complex and lengthy process with objectives varyin...
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Stability Study for EMLA Cream Using In Vitro Percutaneous Absorption
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Stability Study for EMLA Cream Using In Vitro Percutaneous Absorption
EMLA Cream (lidocaine 2.5% and prilocaine 2.5%) is an emulsion in which the oil phase is a...
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CMC Stability Testing As A Quality Control Measure
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CMC Stability Testing As A Quality Control Measure
In this white paper, we introduce the purpose, scope, and type of stability testing requir...
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Development and validation of LC-MS/MS methods for the quantification of the novel anticancer agent guadecitabine and its active metabolite β‑decitabine in human plasma, whole blood and urine
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Development and validation of LC-MS/MS methods for the quantification...
Guadecitabine (SGI-110), a dinucleotide of β‑decitabine and deoxyguanosine, is currentl...
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Development and Validation of an Ultra Sensitive LC-MS/MS Method for Quantitation of Midazolam in Human Plasma
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Development and Validation of an Ultra Sensitive LC-MS/MS Method for...
Midazolam is a widely used central nervous system depressant. It is used for the treatment...
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Validation of a Low-Volume Plasma LC-MS/MS Method Using a CapillaryMicrosampling (CMS) Technique
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Validation of a Low-Volume Plasma LC-MS/MS Method Using a...
With the development of more sensitive instrumentation, there is a greater need for smalle...
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Development and validation of an LC-MS/MS method for the quantification of fascin proteins in human serum
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Development and validation of an LC-MS/MS method for the...
Fascin is an actin-bundling protein that has been linked to tumor cell migration, invasion...
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Simultaneous Determination of Coproporphyrin-I and Coproporphyrin-III in Human Plasms and Human Urine Using LC-MS/MS
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Simultaneous Determination of Coproporphyrin-I and Coproporphyrin-III...
In this study, we developed and validated an LC-MS/MS method for the simultaneous determin...
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Bioanalysis of Liposome Drugs by LC-MS/MS
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Bioanalysis of Liposome Drugs by LC-MS/MS
This webinar presents the history, introduction, applications, and regulatory consideratio...
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A Novel LC-MS/MS Assay for Quantifying Dermatan Sulfate as a Cerebrospinal Fluid Biomarker for Mucopolysaccharidosis II Disease
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A Novel LC-MS/MS Assay for Quantifying Dermatan Sulfate as a...
Accumulation of dermatan sulfate (DS) in tissue and body fluid leads to mucopolysaccharido...
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