AgroChemical Services

Non-GLP and GLP/EPA-Compliant Quantitative Analyses

  • LC/MS/MS based assays
  • Quantitative radioactivity studies

Radio-labeled Studies

  • Mass balance in rodents with specialized expired air-trapping apparatus
  • In vitro metabolism with C14 or 3H-labeled compounds. Comparison with crop metabolites
  • Definitive PK studies (low/high single and multiple dose studies)
  • Tissue distribution studies (necropsy and total radioactive counts in tissues)
  • Special in vivo and in vitro studies including kinetics, bile-duct cannulated, and mechanistic metabolism studies

Synthesis of potential metabolites

  • Compounds up to 2g for initial studies
  • Scale-up to kilo amounts under GMP