Discovery
Medicinal Chemistry Services
Discovery ADME
- Metabolic Stability
- CYP Interaction
- Permeability & Transporters
- Physicochemical Properties
- Protein Binding
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webinar
The human gut microbiome contains a complex aggregate of colonic bacterial enzymes mediating the metabolism of a wide range of xenobiotics and dietary components. This webinar highlights examples of pre-systematic drug clearance mediated by colonic enzymes contributing to systemic metabolite exposure, examines evidence of a causative link between dysbiosis and metabolic disorders, and concludes with an overview of established gut microbiome biomarkers and assay panels available to support investigations in understanding the metabolic fate of xenobiotics and colonic bacterial secondary metabolites.
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