Enhanced Identification Of Polar Carboxylic Acid Metabolites By 2-hydrazinopyridine Derivatization And LC-HRMS/MS

Highly polar metabolites can be difficult to detect using conventional LC-MS methods, potentially leaving important gaps in metabolite profiling. In this ISSX 2026 poster, Frontage scientists explore how 2-hydrazinopyridine derivatization combined with LC-HRMS/MS improves the detection and identification of these challenging metabolites, with promising results across preclinical and clinical samples.

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