Search

Chinese

In Vivo Services

Radiolabeled Studies

In Vivo Services
Services & Solutions / Drug Metabolism & Pharmacokinetics (DMPK) / In Vivo Services / Radiolabeled Studies
IN THIS SECTION
Drug Discovery
Chemistry
Custom Synthesis Medicinal Chemistry Process Chemistry Services & Manufacturing
Biology
ADME • Tox Screening
Metabolic Stability CYP Interaction Permeability & Transporters Physicochemical Properties Protein Binding Metabolite Identification Discovery PK & Toxicology
Pharmacology
Drug Development
Drug Metabolism & Pharmacokinetics (DMPK)
In Vitro Services In Vivo Services
Safety Assessment & Toxicology
Safety Pharmacology Genetic Toxicology Toxicology Global Pathology Services Toxicokinetics Standard for Exchange of Nonclinical Data (SEND)
Clinical Services
About the Clinic Clinical Study Experience Biometrics
Laboratory Testing Services
Bioanalytical – Small & Large Molecules
Method Development & Validation Modalities Technology Platforms Services Assays List Finder
Genomics
Oncology Pharmacogenetics Metagenomics & Microbiome
Central Lab Services
Histology & Pathology Safety Testing & Specialty Lab Testing Biorepository Services Clinical Trial Logistics Services Clinical Sample Processing Biospecimen Data Services Central Lab e-Portal Sample Management Central Lab Clinical Trial Request Intake Form
Biomarkers & Precision Medicine
CMC-Product Development & Manufacturing
Drug Substance Development & Manufacturing
Product Development
Formulation Development Clinical Trial Material (CTM) Manufacturing Commercial Manufacturing
Analytical Services
Analytical Small Molecule Microbiological Services
Biologics Cell & Gene Therapy
Biologics Services Cell & Gene Therapy Services GMP Routine Testing Services Stability Program
Agrochemical

Radiolabeled Studies

At Frontage we provide a comprehensive suite of radiolabeled studies including in-life administration with radiolabeled compounds, mass balance, pharmacokinetics of total radioactivity and the test compound, and metabolite profiling in plasma, urine, and feces.

  • Mass balance and metabolite identification in preclinical species
  • Tissue distribution (QWBA) and dosimetry
  • Mass balance and metabolite identification in human (hAME)
  • Radiolabeled test article synthesis

In vivo metabolism, tissue distribution and mass balance with3H or14C labeled compounds – In life animal dose, sample collection, and sample analysis

  • Single or multiple (repeat) doses via various routes
  • Intact animals (including JVC/FVC) or BDC rats
  • Custom made airtight enclosures for scavenging14C-CO2.
  • Sample collection: 2 to 5 days for metabolite profiles/ID and 5 to 7 days for mass balance

Mass Balance and Metabolite Profiling in Bile Duct Cannulated Rats

Discover the following In Vivo services at Frontage

Resources To Consider

Left arrow
Accurate Mass: The best solution for metabolite identification in discovery, development and clinical applications.
white-paper

Accurate Mass: The best solution for metabolite identification in…
In this paper, we review appropriate definitions and describe the theoretical basis of why…
Access Resource
Full Service Radiolabeled Human C14 AME (hAME) Studies
brochure

Full Service Radiolabeled Human C14 AME (hAME) Studies
Frontage’s Clinical and DMPK teams work together seamlessly to provide full-service radiol…
Access Resource
Quantitative Whole-Body Autoradiography (QWBA) and Radiation Dosimetry​
webinar

Quantitative Whole-Body Autoradiography (QWBA) and Radiation…
This webinar gives an overview of QWBA and hAME study services, an understanding of the gu…
Access Resource
Right arrow