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Resource Library / RNA-Seq Workflow Optimization for Heavily Degraded FFPE Samples with GLP & GCLP Compliance

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RNA-Seq Workflow Optimization for Heavily Degraded FFPE Samples with GLP & GCLP Compliance

We optimized RNA-Seq library preparation for degraded FFPE samples, and our RNA-Seq workflow—fully compliant with GLP and GCLP—demonstrates strong potential for broad application in regulated preclinical and clinical studies, especially when handling highly degraded specimens.

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WRIB 2022: Optimization and standardization of RNA-seq operation to get high-quality sequencing data with heavily degraded RNA samples from tumor biopsies
poster

WRIB 2022: Optimization and standardization of RNA-seq operation to...
We standardized an RNA-seq operation method under Good Lab Practice (GLP) standards, which...
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Optimization and standardization of RNA-seq operation to get high-quality sequencing data with heavily degraded RNA samples from tumor​
poster

Optimization and standardization of RNA-seq operation to get...
To ensure good data yield, there are challenges encountered during NGS operations, especia...
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WRIB 2024: High-quality RNA-seq Library Preparation from Formalin-Fixed Paraffin-Embedded (FFPE) tissues with GLP and GCLP Compliance
poster

WRIB 2024: High-quality RNA-seq Library Preparation from...
Here, we standardized the RNA extraction method from FFPE slides and an RNA-seq operation ...
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Bioanalytical Drug Tolerance Limit Prediction and Optimization Model Developed Through Machine Learning With TensorFlow
poster

Bioanalytical Drug Tolerance Limit Prediction and Optimization Model...
Award winning poster presented at the 14th WRIB

“The selection is based o...
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6 Reasons To Do Exploratory Toxicology for Successful GLP Studies
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6 Reasons To Do Exploratory Toxicology for Successful GLP Studies
Performing robust exploratory tests upfront can save time and money later on in the proces...
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Before GLP: The Value of Robust Exploratory Toxicology
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Before GLP: The Value of Robust Exploratory Toxicology
Frontage's Chris Ryan shares experiences and stories, as well as suggestions for how to se...
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Duplex Sequencing: A Powerful Tool for In Vivo Gene Mutation

Duplex Sequencing: A Powerful Tool for In Vivo Gene Mutation
Discover our EMGS 2025 poster showcasing how Duplex Sequencing (ecNGS) reveals the genotox...
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AAIC 2025: Comparison of Plasma pTau217 Assays on Different Platforms
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AAIC 2025: Comparison of Plasma pTau217 Assays on Different Platforms
Plasma pTau217 was recently discovered as a prominent blood-based biomarker in the early d...
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WRIB 2025: Validation of an Ultra-High Sensitive Simoa Assay for the Quantitation of IL-17A in Human Serum
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WRIB 2025: Innovative Strategy for Overcoming pH-Related Assay Variation in the Development and Validation of a Pharmacokinetic Assay for OBI-992, a TROP2-Targeting Exatecan-Based Antibody-Drug Conjugate, in Human Serum
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WRIB 2025: Integrated Non-cell Based and Cell-based NAb Assays for a Complex oHSV Living Drug
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AACR 2024: Analytical validation of a complete system for detection and characterization of genomic aberrations in circulating tumor DNA
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AACR 2024: Analytical validation of a complete system for detection...
Frontage Laboratories has validated a liquid biopsy NGS assay supporting Gradalis Inc.’s...
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