Discovery
Medicinal Chemistry Services
Discovery ADME
- Metabolic Stability
- CYP Interaction
- Permeability & Transporters
- Physicochemical Properties
- Protein Binding
Frontage combines our in-house clinical and DMPK expertise to provide our clients with a comprehensive approach from initial planning for their human C14 AME (hAME) study through the final study report. A human C14 AME (hAME) study uses a radiolabeled compound to understand how the drug is absorbed, metabolized, and excreted after dosing. The results of such studies elucidate the pharmacokinetics, mass balance, metabolic pathways, and more. hAME studies are typically required for New Drug Applications (NDA) and for some Biologics License Applications (BLA).
Download our full-service hAME brochure.