Quantitation Of Four Chiral Drug Compounds Simultaneously Using Normal Phase LC MS MS Equipped With An APPI Ion Source

Chiral separation is important but also challenging for bioanalysis of the antifungal drug luliconazole. Since typical reverse phase chromatography conditions used in electrospray or APCI- MS/MS could not achieve the required separation of the 4 enantiomers, we employed APPI (Atmospheric Pressure Photo Ionization) conditions instead.

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