Toxicology

Toxicology

Drug safety services to guide new therapies from discovery to full development support

Frontage Laboratories provides toxicology services to guide new therapies from discovery to full development support.  Our extensive profile of IND enabling pivotal studies support swift progression of your lead compounds into the clinic – streamlining your development process.  We provide the resources of a highly skilled, client-focused staff with extensive academic, scientific and pharmaceutical industry experience.

Safety Toxicology Pharmaceutical Laboratory Scientist
Scientist at Frontage Laboratories.

 

IND-enabling studies

  • Regulatory/general toxicity
    • Maximum tolerated dose
    • Dose range-finding – 5-14 days
    • Single and repeat-dose GLP
    • Rodents, dogs, NHP, minipig
    • Complete toxicokinetics support with LC-MS/MS
  • Safety pharmacology
    • ICH core battery: CV, CNS, respiratory
    • Supplemental studies: renal, GI
  • Full clinical and anatomic pathology, ophthalmology, ECG

 Post IND Service

  • Chronic toxicity
  • Juvenile toxicology (Rats)
  • Investigative toxicology
  • Carcinogenicity studies

GLP Analytical Support

  • Dose formulation analysis method development, validation, sample analysis under GLP
  • Bioanalytical method development, validation, sample analysis under GLP, plus pharmacokinetics determination

Animal welfare

Frontage Laboratories, Inc. is committed to the enhancement of animal health and welfare. We honor an organizational commitment toward the ethical and humane use of laboratory animals, paying particular attention to the housing conditions and environmental enrichment of our animal species.