Interleukin17A (IL-17A) is disulfide-linked homo dimeric cytokine of 155 amino acids and a member of an IL-17 family of related cytokines. There is now compelling evidence that patients affected by autoimmune diseases have a higher incidence of several cardiovascular diseases.
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Development and Validation of an LC-MS.MS Method for the Simultaneous Quantitation of Fifteen Bile Acids in Human Serum
In recent years there has been much discussion related to the use of fewer animals for pre-clinical safety and efficacy testing. In addition, regulatory agencies have requested testing in pediatric patient populations for all new drug compounds. With the development of more sensitive instrumentation, the need for smaller blood sample size analysis, has been realized. Over the years, techniques such as Dried Blood Spot (DBS) have been utilized to sample less than 50 uL of blood. While DBS seems to work well for many analyses, the historical PK database for most clinical trials has been through the quantitation of drugs from plasma or serum.
In this infographic, we share the emerging technologies beyond monoclonal antibodies and the bioanalytical methods to support the new technologies.