Metabolite Identification
Comprehensive Drug Metabolism services, applying state-of-the-art techniques and best-in-class approaches to generate data for critical milestones and decision-making.
Comprehensive MetID Solutions for Drug Development
At Frontage Europe, we offer state-of-the-art metabolite identification (MetID) services to support every stage of drug development—from early discovery to clinical trials. Our integrated approach combines high-resolution mass spectrometry, expert data interpretation, and cross-species analysis to deliver actionable insights into the metabolic fate of your compounds.
Why Metabolite Identification Matters
Understanding how a drug is metabolized is critical for:
- Predicting pharmacokinetics and clearance mechanisms
- Identifying active, reactive, or disproportionate metabolites
- Supporting MIST (Metabolites in Safety Testing) and regulatory submissions
- Mitigating risks of drug-drug interactions and toxicity
Our Capabilities
In Vitro MetID
- Hepatocyte, microsome, and S9 fraction incubations
- Soft spot identification and metabolic stability profiling
- Reactive metabolite screening (e.g., glutathione trapping)
In Vivo MetID
- Plasma, urine, feces , bile, and tissue sample analysis
- Cross-species comparison (e.g. human, mice, rat, dog, monkey)
- Radiolabeled studies (14C, 3H)
Advanced Analytical Tools
- LC-MS/MS and UPLC-HR/MS platforms
- Semi-quantification and metabolite profiling down to 0.1% of drug-related material
Specialized Services
- Deuterium exchange and titanium trichloride reduction for structural confirmation
Tailored Reporting & Regulatory Support
We provide:
- Profiles tailored to your project needs (timelines and depth of analysis adjusted according to the number and complexity of metabolites requested)
- Custom PDF and eCTD reports
- Bilingual content (Italian/English) for global accessibility
- Monthly review meetings to align with evolving project needs
Why Choose Frontage Milan
Our Milan site integrates seamlessly with Frontage’s global network, offering:
- Scientific excellence and consultancy
- High-quality data delivery
- Flexible, client-focused solutions
- Alignment with FDA, EMA, and ICH guidelines
Contact Us
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