Exton, PA (Corporate)
For a contract research organization (Frontage Laboratories, Inc. – Exton, PA): perform biologic method transfer, development and validation for drug samples and antibodies; conduct quantitative analysis of drug and metabolites in biological samples utilizing validated liquid chromatography-tandem mass spectrometry (LC-MS/MS); perform immunoassay development; run ligand-binding based bioanalytical assays for Toxicokinetics/Pharmacokinetics (TK/PK) and anti-drug antibodies (ADA) assessments; perform bacterial and cell culture, microscopic cell counting and viability testing; DNA extraction, purification, qPCR and fluorescence detection methods; perform click chemistry, amino acids labeling and protein tagging; comply with all applicable GLPs and regulations.
- Master of Science or foreign equivalent degree in Biotechnology, Biomedical Engineering or a related field.
- 6 months experience in job offered or 6 months research experience. This required experience must include 6 months experience in impurity quantitation and isolation, particle size analytical techniques, HPLC, drug excipient screening and quantitation, formula (QbD) optimization, GC, LC-MS/MS and UPLC. Experience can be gained while pursuing degree.
- Proficiency in fluorescent molecular imaging techniques and quantitative molecular imaging, biohazard materials handling, sample extraction from biological sources, mouse dissection, animal anesthesia & intravenous (IV) administration, basic pipetting, protein labeling and purification, imaging agent preparation and cell culture techniques.
Work Location: Exton, PA.
Hours: 40 per week – Monday through Friday.