Publications

Please review the following papers and posters developed by Frontage scientific personnel and clients.

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Papers  

 

A Highly Sensitive and Selective Method for the Determination of Leukotriene B4 (LTB4) in Ex-vivo Stimulated Human Plasma by Ultra Fast Liquid Chromatography–Tandem Mass Spectrometry.  Weisheng Lin (a), Mike-Qingtao Huang(b), Xiaohua Xue(c), Kirk Bertelsen(d), Guiyan Chen(a), Harry Zhao(a), Zhongping John Lin(a), Anne Fourie(c), Jan de Jong(c), Naidong Weng(b).  (a ) Frontage Laboratories Inc., Exton, PA; (b)  Janssen Research & Development, LLC, South, Raritan, NJ; (c)  Janssen Research & Development, LLC,  San Diego, CA; (d)  Janssen Research & Development, LLC,  Titusville, NJ. http://dx.doi.org/10.1016/j.jchromb.2013.02.038

 

Bioanalysis of drug in tissue: current status and challenges.  Y-J Xue, Hong Gao, Qin C Ji, Zamas Lam, XinPing Fang, Zhongping (John) Lin (Frontage), Matthew Hoffman, Daniel Schulz-Jander & Naidong Weng.  Review Special Focus Issue: Tissue bioanalysis, Bioanalysis (2012) 4(21), 2637–2653.

 

Determination of metformin in rat plasma by HILIC-MS/MS combined with Tecan automation and direct injection. Wei Zhanga, Futian Hana, Harry Zhaoa, Zhongping (John) Lina*, Qingtao (Mike) Huangb and Naidong Weng Biomedical Chromatography. Vol 26, Issue 10, pages 1163–1169, October 2012.


A pilot study for a pivotal bioequivalence trial using two paroxetine 40 mg tablet formulations in healthy Chinese subjects.  Shengjun Zhang1, Quancheng Kan 1, Jianguo Wen1, Jie Zhao 1, Yuqiao Sheng 1, Yidong Li 1, Suke Sun 1, Feng Zhang 1, Li Yang 1, Wenzhe Lv 2, Yuanchao (Derek) Zhang 2, Kun Qian 2 and Zhongping John Lin 2. (1) The First Affiliated Hospital of Zhengzhou University, Henan Province, Zhengzhou, Henan, China and (2) Frontage Laboratories, Inc., Exton, PA.   International Journal of Clinical Pharmacology and Therapeutics, 2012 Jul;50(7):514-23.

 

Hemolysis of Blood Samples has no Significant Impact on the Results of Pharmacokinetic Data Jie Zhao1, Quancheng Kan 1, Jianguo Wen1, Yidong Li1, Yunqiao Sheng1, Li Yang1, Jason Wu2 and Shengjun Zhang1 (1) Zhengzhou University First Affiliated Hospital, 1 E. Jianshe Road, Zhengzhou, Henan 450052, P.R. China.  Frontage Clinical Services, 224 Valley Creek Blvd. Suite 300, Exton, PA.  J Bioequiv Availab Volume 4(6): 082-085 (2012) - 082 July 26, 2012.

 

Pharmacokinetics of daily self-application of imiquimod 3.75% cream in adult patients with external anogenital warts. Wu J, Feldman R, Barry GT, Kulp J, Adams MP, Levy S. J Clin Pharmacol. 2012 Jun;52(6):828-36.

 

Considerations For Strategic Partnering with CRO/CMOs: Incorporating QbD Early In Product Development Is Key To Success. A case study examining QbD in development and scale-up of ophthalmic dosage forms.  Ron Connolly, Vaishali Ketkar, Amit Shah, and Veerarajendra (Raj) Yadwad; Frontage Laboratories, Inc., Exton, PA. Pharmaceutical Online: The Magazine. March 28, 2012 

 

Imiquimod 3.75% Cream Applied Daily to Treat Anogenital Warts: Combined Results from Women in Two Randomized, Placebo-Controlled Studies. David A. Baker Daron G. Ferris, Mark G. Martens, Kenneth H. Fife, Stephen K. Tyring, Libby Edwards, Anita Nelson, Kevin Ault, Kenneth F. Trofatter, Tiepu Liu, Sharon Levy,10 and Jason Wu (Frontage).  Infectious Diseases in Obstetrics and Gynecology Volume 2011, Article ID 806105.




Capsule Review on Bioanalytical Method Transfer: Opportunities and challenges for chromatographic methods Zhongping (John) Lin 1, Wenkui Li 2 and Naidong Weng 3(1) Frontage Laboratories, Inc., 105 Great Valley Parkway, Malvern, PA, USA (2) Novartis Institutes for Biomedical Research, East Hanover, NJ, USA (3) Johnson & Johnson Pharmaceutical Research & Development, LLC, Raritan, NJ 08869, USA. Bioanalysis 2011 Jan;3(1):57-66.

 

Simultaneous determination of tolbutamide, omeprazole, midazolam and dextromethorphan in human plasma by LC–MS/MS—A high throughput approach to evaluate drug–drug interactions. Wei Zhang (a), Futian Han (a), Ping Guo (a), Harry Zhao (a), Zhongping (John) Lin (a), Mike-Qingtao Huang (b), Kirk Bertelsen (c), Naidong Weng (b). (a) Frontage Laboratories, Inc., 105 Great Valley Parkway, Malvern, PA (b) Johnson & Johnson Pharmaceutical Research & Development, LLC, Raritan, NJ (c) Johnson & Johnson Pharmaceutical Research & Development, LLC, San Diego, CA. Journal of Chromatography Analyt Technol Biomed Life Sci. 2010 May 1;878(15-16):1169-77.

 

A Highly Specific and Sensitive LC/MS/MS Assay for Itraconazole and Hydroxy-Itraconazole in Human Plasma for Bioequivalence, Bioavailability and Pharmacokinetic Studies Wei Zhang, Futian Han, Harry Zhao, Zhongping (John) Lin and Guillermo Tous.  Frontage Laboratories, Inc., Malvern, PA.

 

Posters

 

A Generic Approach for Absolute Quantitation of the Monoclonal Antibody BAN2401 in Human Serum Using Immunocapture and Mass Spectrometric Detection
Zhaoyuan (Tony) Chen 2, Luca Matassa 1, Robert Lai 1, Jing Ke 2, Zhongping John Lin 2, Huachun Chen 1, Kenan Gu 1.  (1) Eisai Inc., Woodcliff Lake, NJ; 
(2) Frontage Laboratories, Inc., Malvern, PA.

 

Simultaneous Determination of Ethinyl Estradiol, Norgestimate and 17-Desacetyl Norgestimate at 2/5 pg/mL Level in Human Plasma by LC-MS/MS.  Jing Ke; Kelly Lam; Weisheng Lin; Harry Zhao; Zhongping (John) Lin; Frontage Laboratories, Inc., Malvern, PA.

  

A Novel and Ultrasensitive APPI LC-MS/MS Method (0.2 pg/mL) for Determination of Fluticasone Furoate in Human Plasma Jing Ke, Weisheng Lin, Harry Zhao and Zhongping (John) Lin; Frontage Laboratories, Inc., Malvern, PA.

 

Determination of metformin in rat plasma by HILIC-MS/MS combined with Tecan automation and direct injection. Wei Zhang 1, Futian Han 1, Harry Zhao 1, Zhongping (John) Lin 1, Mike-Qingtao Huang 2, Naidong Weng 2 (1) Frontage Laboratories, Inc., Malvern, PA (2) Johnson & Johnson Pharmaceutical Research & Development, LLC, Raritan, NJ. 

 

Simultaneous Determination of Tolbutamide, Omeprazole, Midazolam, and Dextromethorphan in Human Plasma by LC/MS/MS – A High Throughput Approach to Evaluate Drug-drug Interactions Wei Zhang, Futian Han, Ping Guo, Harry Zhao, Zhongping (John) Lin, Mike-Qingtao Huang, Kirk Bertelsen and Naidong Weng.  Frontage Laboratories, Inc., Malvern, PA.


Quantification of Naringinen, Bergamottin, and 6’, 7’-Dihydroxybergamottin-Three Major Components in Grapefruit Juice by LC/MS/MS.  
Yafei Xu, Jing Ke, Harry Zhao and Zhongping (John) Lin.  Frontage Laboratories, Inc., Malvern, PA.

 

Posters presented at 2010 ASMS Annual Meeting 

 

Determination of 2,2-Dimethylbutyrate (HQK-1001) in Human Plasma and Urine by LC-MS/MSWeimin Wang 1, Ping Guo 1, Futian Han 1, Jing Ke 1, Harry Zhao 1, Zhongping (John) Lin 1, Patrick Bobbitt 2 (1) Frontage Laboratories, Inc., Malvern, PA; (2) HemaQuest Pharmaceutical Inc., Seattle, WA.

 

The Use of Human Dried Blood Spot (DBS) Samples for the Quantification of Clarithromycin by LC-MS/MS Using Core-Shell HPLC Column.  Jing Ke 1; Li Zhang 2; Qiaoling Yu 2; Harry Zhao 1; Zhongping (John) Lin 1 (1) Frontage Laboratories, Inc., Malvern, PA; (2) Frontage Laboratories (Shanghai) Co. Ltd., Zhangjiang High-Tech Park, Shanghai, China.

 

A Novel Liquid Chromatography Tandem Mass Spectrometry (LC-MS/MS) Method for the Determination of Riluzole in Human Serum. Weimin Wang 1, Hsiaoju Lin 1, Jing Ke 1, Harry Zhao 1, Zhongping (John) Lin 1, Paul Grant 2, Susan E. Swedo 2 (1) Frontage Laboratories, Inc., Malvern, PA; (2) National Institute of Mental Health, NIH, Bethesda, MD.

 

Determination of Metformin in Rat Plasma by HILIC-MS/MS Combined with Tecan Automation and Direct Injection. Wei Zhang 1, Futian Han1, Harry Zhao1, Zhongping (John) Lin 1, Mike-Qingtao Huang 2, Naidong Weng 2  (1) Frontage Laboratories, Inc., 105 Great Valley Parkway, Malvern, PA 19355 (2) Johnson & Johnson Pharmaceutical Research & Development, LLC, Raritan, NJ.

 

Determination of Leukotriene B4 (LTB4) in Human Plasma by UFLC-MS/MS – A Novel Approach to Evaluate LTB4 as a Pharmacodynamic (PD) Biomarker in Pharmaceutical Development. Mike-Qingtao Huang 1, Naidong Weng 1, Weisheng Lin 2, Futain Han 2, Hsiaoju Lin 2, Zhongping (John) Lin 2, Xiaohua Xue 3, Anne Fourie3 , Ann Welton 3, Kirk Bertelsen 3 and Jan de Jong 3. (1) Johnson & Johnson Pharmaceutical Research & Development, LLC, Raritan, NJ (2) Frontage Laboratories, Inc., Malvern, PA; (3) Johnson & Johnson Pharmaceutical Research & Development, LLC, San Diego, CA.

 

Quantification of Letrozole in Human Plasma by LC-MS/MS Employing A Core-Shell Technology Column. Yafei Xu; Jing Ke; Harry Zhao; Zhongping (John) Lin, Frontage Laboratories, Inc., Malvern, PA.