Preclinical Formulation Development

After selecting a lead drug candidate, you may face several hurdles to ensuring the successful delivery of the molecule to the target site of treatment.

 

In some cases, the most frustarting challenges are those that are due to the physico-chemical properties of the drug substance itself.  These include solubility, membrane permeability, stability and interactions with formulation excipients. 

 

With our innovative approach, Frontage excels at solving complex problems with speed and efficiency that few competitors can match.  When it comes to formulation development, we have helped clients develop rational and creative strategies by incorporating Quality by Design (QbD) principles.

 

Quality by Design for Quick Prototype Development

 

Using QbD in the early stages of the drug development process leads to quick prototype development because critical knowledge is obtained up front.  This knowledge includes the product attributes, process parameters, material attributes and operation controls required for the formulation and its manufacturing process.

 

You too can clear the hurdles of formulation development by working with the team of experienced professionals at Frontage. 

 

Implementing a rational, stepwise approach to QbD throughout the preclinical and clinical stages of product development will allow the development team to create an optimized formulation and a robust, scalable process earlier in the timeline and may avoid the potential for clinical failure of the candidate due to bioavailability or absorption issues.

 

To achieve these advantages, partner with Frontage team members who are familiar with implementing the QbD concepts in various types of product development programs and have a proven track record of successfull scaled-up processes.  Allow us to add efficiencies and effectiveness to your drug development program.