Finished Product Development

Frontage understands that formulation is critical to the success of your drug candidate. Our staff of skilled scientists has over 100 years of collective industry experience, delivering many complex formulations on-time and within budget. We take a collaborative approach with our sponsors and treat each project uniquely, exploring multiple technology platforms in order to increase the rate of success for each product.

 

Preformulation studies at Frontage are designed to identify the best form of the drug substance, evaluate its physical properties and learn about its stability. These studies are designed to identify and select the optimal dosage form of your API. Formulation development and pre-formulation studies include:

  • API-excipients compatibility

  • Excipient-excipient compatibility

  • Dissociation constant

  • Solubility in various media and solvents

  • Thermal characterization

  • Droplet size distribution

  • Wettability

  • Density

  • Polymorphic forms

  • Partition coefficient

  • Stability under various conditions

  • Particle size distribution

  • Surface area

  • Flowability

  • Compressibility

  • Cell membrane permeability

Experience
Frontage formulators have significant experience in the development of a wide variety of dosage forms, including:


Oral Solid

  • Immediate release

  • Timed or delayed release

  • Controlled or sustained release tablets

  • Controlled or sustained release capsules

  • Orally disintegrating and chewable tablets

Liquid

  • Injections

  • Ophthalmic drops

  • Suspensions and solutions (including sterile suspensions)

  • Emulsions

  • Lyophilization (cycle development, phase transfer studies and scale-up)

Other Dosage Forms

  • Sublingual tablets

  • Effervescent tablets

  • Liquid fill or semi-solid fill capsules

  • Chewable tablets

  • Buccal tablets

  • Transdermal patches

  • Creams and ointments

  • Nasal sprays

  • Inhalation