Clinical Biomarkers & Immunogenicity
Clinical biotherapeutics development demands expertise and cutting edge resources. Frontage supports your unique needs in this area with advanced methods and technologies for large molecule bioanalytical/immunogenicity and biomarker testing. Rely on Frontage's Biological Services to fulfill your needs for preclinical and clinical pharmacokinetic (PK) and immune anti-drug antibody (ADA) testing.
In PK testing, Frontage services include:
- Protein therapeutic concentration, and
- WIN NonLin (PK parameters; modeling)
Our Immunogenicity Services include:
- Antibody screening (ADA, Immunogenicity)
- Antibody titration
- Neutralizing cell-based immunogenicity characterization
Frontage's biologics team has developed a range of specialized assays that predict drug efficacy and toxicity. Below is a sample of specialized assays available to you. Our capabilities and technology enable us to develop other specialized assays depending on your needs.
Cell-Based Assays (Preclinical and Clinical)
- In Vitro
- Ex Vivo
- Cell lines, primary cell culture and whole blood components
- Potency assay
- Proliferation assays
- Immune function assays (NAB)
- Custom assay development
Pharmacogenomics & Molecular Biology Testing
In addition to our specialized assays, Frontage offers a host of biomarker assays and the capacity to develop new ones upon request.